Effects of teriparatide, denosumab, or both on spine. Trabecular bone score tbsa novel method to evaluate. Tbs, which is assessed by lumbar spine dualenergy xray absorptiometry dxa imaging, provides information about the microarchitectural deterioration of bone tissue. Bone strength is predominantly determined by bone density, but bone microarchitecture also plays an important role. Trabecular bone score in healthy ageing the british. The association between trabecular bone score and incident fractures in adults with reduced kidney function and whether this association differs from that of. One of the most recent and extensively studied determinants of fracture risk is trabecular bone score tbs. We examined whether trabecular bone score tbs predicts the risk of vertebral fractures in a japanese female cohort.
Trabecular bone score may improve frax prediction accuracy. Microstructural parameters of bone evaluated using hrpqct. A trabecula plural trabeculae, from latin for small beam is a small, often microscopic, tissue element in the form of a small beam, strut or rod that supports or anchors a framework of parts within a body or organ. Over the past 5 years, numerous publications, communications in congresses and meetings of scientific societies have been generated. Evaluation of the potential use of trabecular bone score to. Assessing bone quality and fracture risk in patients with osteoporosis in 2012 the fda approved a new diagnostic tool for assessing fracture risk in people with osteoporosis. We offer dxa and ultrasonometer systems for a wide range of clinical and research applications. Mar 22, 20 pothuaud l, barthe n, krieg ma, mehsen n, carceller p, hans d. This information complements bone mineral density measurement, and can be helpful to clinicians in determining fracture risk and discussing lifestyle management or treatment options with patients. Evaluation of the potential use of trabecular bone score. Medical use medimaps group we understand bone health. Pothuaud l, barthe n, krieg ma, mehsen n, carceller p, et al.
Dual energy xray absorptiometry dxa is considered the most highly developed and most thoroughly validated technique for assessing bone mineral density, according to the world health organizations report on the prevention and. By using the tbs insight software medimapstbs version 1. Reference ranges for trabecular bone score in australian men. Didier hans center for bone diseases, dal lausanne university hospital, switzerland. Trabecular bone score may improve frax prediction accuracy for major osteoporotic fractures in elderly japanese men. Trabecular bone score tbs from fracture prediction to clinical use teheran may 2016 prof. Trabecular bone score tbs is a novel method for indirectly assessing. The measurement is performed using dualenergy xray absorptiometry dxa images acquired from a bone mineral densitometry bmd scan, and results can be interpreted by physicians to. Assessment of fat distribution and bone quality with trabecular bone score tbs in healthy chinese men skip to main content thank you for visiting. The tbs is used to evaluate pixel gray level variations in the spine on dxa images and is related to bone microarchitecture and fracture risk, thereby providing information independent of bmd. Trabecular bone score and incident fragility fracture risk.
Introduced in 2008, its main projected use is alongside measures of bone density in better predicting fracture risk in people with metabolic bone problems. Tbs insight software installs on existing dxa scanners. Tbs insight bone density software dexa solutions, llc. Trabecular bone score tbs uses standard lumbar spine dxa imaging to assess bone texture inhomogeneity that is, the number of filled versus unfilled voxels in order to gauge bone quality and fracture risk. The trabecular bone score tbs is a novel tool used to evaluate bone microarchitecture. Trabecular bone score as an assessment tool to identify. The range of youngs modulus for trabecular bone is 80014000 mpa and the strength of failure is 1100 mpa. The tbs is a useful additional score of bone health, which may help to better define fracture risk. Trabecular bone score no units the trabecular bone score tbs is an indirect measure of the microarchitecture of the trabeculae, or lattice structures, that compose the trabecular spongy bone in the lumbar spine. Largest study to date investigating the role of tbs in populations worldwide concludes that tbs is a significant and consistent predictor of fracture risk independent of. Trabecular bone score tbs as a new complementary approach for osteoporosis evaluation in clinical practice. As a greylevel textural parameter, the tbs yields additional information on bone texture that is independent of areal bone mineral density abmd. It is conveniently measured during a standard bone density test. Quibim is proud to introduce its new advanced methodolgy to assess bone quality and fracture risk.
Bone age as a correction factor for the analysis of. The trabecular bone score tbs is a graylevel textural metric that can be extracted. Leveraged first in the field of osteoporosis as the gold standard for bone microarchitecture assessment on dxa in osteoporosis making a difference in patient lives. Trabecular bone score validated as standalone predictor of. Bone mass and quality decline with age, leading to compromised strength and increased fracture risk. It is measured by evaluating graylevel variations in the pixels of an anteriorposterior lumbar spine dxa scan. The need for a reliable approach for the characterization of trabecular microarchitecture is evident, as conditions and diseases related to trabecular bone quality and structure are becoming a focal point of precision medicine. The output of frax can now be adjusted for trabecular bone score tbs. Trabecular bone score, a bone microarchitecture index, may improve frax prediction accuracy for major osteoporotic fractures in communitydwelling elderly japanese men. Pdf trabecular bone score may improve frax prediction. This feature was built based on a prospective study of more than 30,000 patients and.
The trabecular bone score tbs is a new parameter that is determined from graylevel analysis of dualenergy xray absorptiometry dxa images. A study of the value of trabecular bone score in fracture. Recently tbs data has been used to optimize the fracture risk assessment tool frax predictive value. The trabecular bone score is a measure of grey scale homogeneity obtained from spine dxa, which correlates to trabecular microarchitecture and is an independent risk factor for fracture. The trabecular bone score tbs is a new texture parameter obtained from the analysis of dualenergy xray absorptiometry dxa images. The result is expressed as a trabecular bone score. As you know, osteoporosis diagnosis and management remain a challenge. Trabecular bone score tbs as a new complementary approach for. A trabecula generally has a mechanical function, and is usually composed of dense collagenous tissue such as the trabecula of the spleen. Ge healthcare is a market leader in bone health and metabolic health. Tbs can be readily applied to a dxa image through the use of a specific software, and has an attractive feature which is the possibility of being retrospectively cal culated from an existing dxa image without the need for further imaging 12. To do so, tbs utilizes a software program installed on a standard dxa computer to. Trabecular bone score page 1 of 2 trabecular bone score or tbs provides information about bone structure that complements bone density measurement, and can be conveniently measured during a standard bone density test we are. Trabecular bone score tbsa novel method to evaluate bone.
Commons attribution license, which permits use, distribution and reproduction in any. The trabecular bone score tbs is a recently developed skeletal score that is derived from lumbar spine dual energy xray absorptiometry dxa images. Trabecular bone score tbs is a novel texture parameter to evaluate bone. A low tbs value has been independently associated with increased fracture risk. Microstructural parameters of bone evaluated using hrpqct correlate with the dxaderived cortical index and the trabecular bone score in a cohort of randomly. New fracture risk assessment software available for dxa there is a new bone texture parameter called tbs trabecular bone score, available now to add to your dxa bone density system with the software tbs insight. Thats why bone densitometry has evolved significantly over the past few. Using the trabecular bone score tbs application, you can also study the bone quality and the bone microarchitecture of the bone to achieve added clinical diagnostic confidence. Tbs can be readily applied to a dxa image through the use of a specific software. Over the past several years, the hardware and software. Calculated by tbs insight software which installs on existing dxa scanners, tbs is a simple method that estimates fracture risk based on a determination of bone texture an index correlated to bone microarchitecture. Trabecular bone score as a supplementary tool for the. Crosssectional and prospective studies, involving a large number of subjects, have. Published articles in english and french were extracted.
Trabecular bone score validated as standalone predictor of fracture risk. This software looks at the distribution of the bone within the vertebral body on a two dimensional image acquired by the dxa machine. Use of dual energy xray absorptiometry, the trabecular. Evaluation of the potential use of trabecular bone score to complement bone mineral density in the diagnosis of osteoporosis. One such parameter is trabecular microarchitecture, including trabecular distribution and connectivity, which can be indirectly measured by trabecular bone score tbs. It is a textural index that evaluates pixel greylevel variations in the lumbar spine dxa image, thereby providing an indirect index of trabecular microarchitecture 11. Since patients receiving glucocorticoid are at a higher risk of developing secondary osteoporosis, assessment of bone microarchitecture may be used to evaluate risk of fragility fractures of osteoporosis. Preoperative bone health assessment and the potential use of. Moreover, longitudinal and prospective studies have suggested that the tbs is. Trabecular bone score in active or former smokers with and without. Explore our dxa and qus bone and metabolic health portfolio by learning more about our products and clinical applications.
Potential sources of this ageassociated decline in bone quality include. How it works easily installed on a dxa machine, this software application uses the dxa 2d images produced during a regular spine bone mineral density bmd scan to seamlessly compute a patients trabecular bone score within seconds. The incorporation of new technological applications in the medical field entails a prolonged period of evaluation of the scientific evidence generated in the clinical validation process. Trabecular bone score tbs is a softwarebased tool for the analysis of dxa images to assess bone microarchitecture in the lumbar region. Background and objectives trabecular bone score is a graylevel textural measure obtained from dual energy xray absorptiometry lumbar spine images that provides information independent of areal bone mineral density. A team of international researchers has now validated the predictive ability of trabecular bone score tbs using individuallevel data of 17,809 men and women from 14 studies worldwide. A recently developed diagnostic tool, trabecular bone score tbs, can provide quality of trabecular microarchitecture based on images obtained from dualenergy xray absorptiometry dxa. The aim of this study was to evaluate the clinical value of tbs on frax algorithm. Trabecular bone score tbs predicts vertebral fractures. Trabecular bone score tbs from fracture prediction to clinical use teheran may 2016. Assessment of fat distribution and bone quality with.
Use of dual energy xray absorptiometry, the trabecular bone. Trabecular bone score tbs is an index of bone microarchitecture that provides additional skeletal information to areal bone mineral density abmd. Tbs insight is a unique, easytouse software application that assesses bone texture an index of bone microarchitecture which in turn is expressed as the trabecular bone score tbs. Trabecular bone score tbs uses standard dual energy xray absorptiometry to.
The relationship between modulus of trabecular bone and its apparent density was demonstrated by carter and hayes in 1976. As mentioned above, the mechanical properties of trabecular bone are very sensitive to apparent density. New fracture risk assessment software available for dxa. The trabecular bone score predicts spine fragility fractures in. Trabecular bone score and incident fragility fracture risk in. The trabecular bone score is a measure of bone texture correlated with bone microarchitecture and a marker for the risk of osteoporosis. The application of the trabecular bone score tbs has also received the. Reference ranges for trabecular bone score in australian. Tbs insight serves as a foundation technology for tissue structure assessment software applications. Apr 26, 2016 one of the most recent and extensively studied determinants of fracture risk is trabecular bone score tbs. Trabecular bone score tbs uses standard dual energy xray absorptiometry to measure how wellstructured the trabecular bone appears when assessed as individual voxels. Trabecular bone score page 1 of 2 osteoconnections. The result expressed as a trabecular bone score tbs derives from a patented algorithm that evaluates pixel graylevels and spatial variations in the ap spine dxa scan, providing an indirect, yet highly.
The trabecular bone score tbs uses twodimensional scans obtained during. In girls, tbs value using ba is constant until age 8, and in boys until age 10, and then starts to increase steadily. The association between trabecular bone score and incident fractures in adults with reduced kidney function and whether this association differs from that of adults with normal. Since that time, trabecular bone score tbs has rapidly made its way into the clinical setting. The measurement is performed seamlessly using dxa images acquired from a bone mineral densitometry bmd scan. The main aim of this work was to report on trabecular bone score tbs by dualenergy xray absorptiometry dxa of healthy italian subjects to be used as a reference standard for future study in clinical and research settings. Since the clinical utility of a diagnostic test is that of adding information to that. Trabecular bone score tbs predicts vertebral fractures in. Trabecular bone score tbs is a recentlydeveloped analytical tool that.
Trabecular bone score tbs is a software based tool for the analysis of dxa images to assess bone microarchitecture in the lumbar region. Search strategy a medline search for publications with the terms trabecular bone score or tbs was undertaken in september 2014. A new approach for measuring the trabecular bone density. The trabecular bone score tbs is a textural measurement derived from lumbar spine d ualenergy xray absorptiometry dxa images.
An additional software to further analyze the dxa images of the spine is known as trabecular bone score tbs. Purpose trabecular bone score tbs is a softwarebased method for indirect assessment of trabecular bone structure of the spine, based on analysis of pixels in dual energy xray absorptiometry. Mar 10, 2015 frax is widely used to evaluate fracture risk of individuals in clinical settings. There is a new bone texture parameter called tbs trabecular bone score, available now to add to your dxa bone density system with the software tbs insight.
Jun 03, 2015 new fracture risk assessment software available for dxa there is a new bone texture parameter called tbs trabecular bone score, available now to add to your dxa bone density system with the software tbs insight. Mar 31, 2016 trabecular bone score or tbs provides information about the quality of bone structure in the spine bone. To better understand the potential clinical utility of tbs in smokers, the. Frequency of osteoporotic fractures, parameters of bone. It relies on the mean thickness and volume fraction of trabecular bone microarchitecture.
Recent data demonstrate the potential utility of the trabecular bone score adjustment of afr through the frax algorithm in subjects with ckd. Simulated increased soft tissue thickness artefactually. Trabecular bone score tbs is a novel graylevel textural analysis. Trabecular bone scan tbs insight is an imaging software application that assesses bone texture which in turn is expressed as the trabecular bone score tbs. Cross sectional and prospective studies, involving a large number of subjects, have. Pothuaud l, barthe n, krieg ma, mehsen n, carceller p, hans d.
Trabecular bone score as a supplementary tool for the discri. Review of the scientific evidence regarding clinical use. It computes a trabecular bone score tbs, which provides extremely useful additional clinical information as to the microarchitecture of the bone. High tbs degraded trabecular bone architecture heterogeneous. Trabecular bone score or tbs provides information about the quality of bone structure in the spine bone. It is an index of bone microarchitecture that provides skeletal information complementary to that obtained from standard bone mineral density bmd measurement. Thats why bone densitometry has evolved significantly over the past few years. Trabecular bone score as an assessment tool to identify the. This data may help widen tbs use in pediatric populations. Trabecular bone score tbs as a new complementary approach. The role of trabecular bone score and hip geometry in.
869 934 603 1513 1176 213 516 1000 124 1246 1611 434 337 442 192 396 1540 728 286 1515 1457 1348 1644 793 99 344 653 136 67 1241 1384 714 1351 561